Reveromycin T 1-methyl ester and 1-ethyl ester
- Structure
-
Reveromycin T 1-methyl ester:
Reveromycin T 1-ethyl ester:
- Producing organism
- Streptomyces reveromyceticus SN-593
- Biological activity
- cytotoxicity against mammalian cancer cells
- Abstract
- Two new reveromycin derivatives, reveromycin T 1-methyl ester and 1-ethyl ester were created by adding a small amount of related alcohol, methanol and ethanol, to culture broth of S. reveromyceticus SN-593 during the fermentation. Their cytotoxic activity against HL-60, K562, and tsFT210 cell lines were evaluated and they showed moderate cytotoxicities. Similar approach to create new metabolites has not been reported before, and this simple method might be applied to other metabolites to expand their chemical diversity.
- References
- Nogawa T, Takahashi S, Sekiyama Y, Takagi H, Uramoto M, Koshino H, Kawatani M, Shimizu T, Osada H.: Creation of novel reveromycin derivatives by alcohol-added fermentation.
J Antibiot, 66(4): 247-250 (2013)
[ doi: 10.1038/ja.2012.115 ]- Nogawa T, Takahashi S, Sekiyama Y, Takagi H, Uramoto M, Koshino H, Kawatani M, Shimizu T, Osada H.: Creation of novel reveromycin derivatives by alcohol-added fermentation.