FSL0406
- Structure
- InChI=1S/C16H24N2O4/c1-10(2)8-13(16(21)22)18-15(20)14(19)12(17)9-11-6-4-3-5-7-11/h3-7,10,12-14,19H,8-9,17H2,1-2H3,(H,18,20)(H,21,22)/t12-,13?,14+/m1/s1
- InChIKey=VGGGPCQERPFHOB-YIOYIWSBSA-N
- Synonyms
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- (-)-Bestatin
- 58970-76-6
- Bestatin
- NK 421
- NSC 265489
- Ubenimex
- Origin
- Streptomyces olivoreticuli
- Biological activities
- Inhibition of aminopeptidase B
- Therapeutic
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Anticancer
- Target
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Aminopeptidase B
- Assay information
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Bestatin competitively inhibits leucine aminopeptidase with IC50 value of 0.01 μg/mL and shows the growth inhibitory activity against human leukemic cell lines (P39/TSU, HL60, U937, THP1, K562; IC50 = 0.48-6.4 μg
- References
-
-
Sekine K, Fujii H, Abe F
Induction of apoptosis by bestatin (ubenimex) in human leukemic cell lines.
Leukemia, 13(5): 729-734 (1999) 10374877
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Umezawa H, Aoyagi T, Suda H, Hamada M, Takeuchi T
Bestatin, an inhibitor of aminopeptidase B, produced by actinomycetes.
J Antibiot, 29(1): 97-99 (1976) 931798