NPEdia

(+)-Staurosporine

Structure
(+)-Staurosporine
Synonyms
Origin
Actinomycete N96C-47
Lentzea albida
Biological activities
Broad kinase inhibition
Therapeutic
Anticancer
Antifungal
Target
Protein kinases
Assay information
Inhibition of several kinds of protein kinases (IC50 [nM]): protein kinase C (2.7), protein kinase A (22), protein kinase G (8.5), tyrosine kinase (6.4), myosin light chain kinase (5), cdc2 (4)
Cytotoxicity (IC50 [μM]): HeLa S3 cells (0.28)
Antibacterial activity (MIC [μg/ml]): C. albicans (6.25), A. fumigatus (12.5)
References