NPEdia

FSL0879

Structure
FSL0879
Synonyms
Origin
Streptomyces griseus
Biological activities
Inhibition of bacterial protein synthesis
Therapeutic
Antibacterial
Antituberculosis
Target
30S ribosomal protein S12
Assay information
Binding to ribosomal protein S12, a 30S subunit of the bacterial ribosome, causing protein synthesis inhibition
Antibacterial activity against Gram-(+) strains (MIC [μg/ml]: S. aureus, 0.125; B. subtilis, 0.25; E. coli, 1.0; P. aeruginosa, 0.5; M. kansasii, 3.13; M. intracellulare, 12.5)
Inhibition of the binding of the Tat protein to mRNA with IC50 of 9.5 μM
References