FSL0404
- Structure
- InChI=1S/C20H18NO4.ClH/c1-22-17-4-3-12-7-16-14-9-19-18(24-11-25-19)8-13(14)5-6-21(16)10-15(12)20(17)23-2;/h3-4,7-10H,5-6,11H2,1-2H3;1H/q+1;/p-1
- InChIKey=VKJGBAJNNALVAV-UHFFFAOYSA-M
- Synonyms
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- Origin
- Berberis sp.
- Biological activities
- Wide range of pharmacological activities.
- Therapeutic
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Antibacterial
Anticancer
Antidiabetes
Antifungal
Antiinflammation
Antiviral
- Target
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RNA transcription
Kinase inhibition
- Assay information
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Antifungal activity: MIC =1 μg/mL
Nasopharyngeal Carcinoma Ezrin Phosphorylation (Rho Kinase Ki=0.35 μM)
Adipocyte differentiation (CREB Transcriptional Activity)
Berberine inhibits proliferation of various cancer cell types (IC50 = 30-100 μM)
- References
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Xiao CW, Ji QA, Wei Q, Liu Y, Bao GL
Antifungal activity of berberine hydrochloride and palmatine hydrochloride against Microsporum canis -induced dermatitis in rabbits and underlying mechanism.
BMC Complement Altern Med, 15: 177 (2015) 26054937 doi: 10.1186/s12906-015-0680-x
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Zhang J, Tang H, Deng R, Wang N, Zhang Y, Wang Y, Liu Y, Li F, Wang X, Zhou L
Berberine Suppresses Adipocyte Differentiation via Decreasing CREB Transcriptional Activity.
PLoS One, 10(4): e0125667 (2015) 25928058 doi: 10.1371/journal.pone.0125667
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J. Nat. Prod., 3: 64-75 (2010)
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Tang F, Wang D, Duan C, Huang D, Wu Y, Chen Y, Wang W, Xie C, Meng J, Wang L, Wu B, Liu S, Tian D, Zhu F, He Z, Deng F, Cao Y
Berberine inhibits metastasis of nasopharyngeal carcinoma 5-8F cells by targeting Rho kinase-mediated Ezrin phosphorylation at threonine 567.
J Biol Chem, 284(40): 27456-27466 (2009) 19651779 doi: 10.1074/jbc.M109.033795
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Berberine.
Altern Med Rev, 5(2): 175-177 (2000) 10767672
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Cromwell BT
Experiments on the origin and function of berberine in Berberis Darwinii.
Biochem J, 27(3): 860-872 (1933) 16745167