FSL0896
- Structure
- InChI=1S/C14H12N4O2S.Na.H/c15-10-5-7-11(8-6-10)21(19,20)18-14-9-16-12-3-1-2-4-13(12)17-14;;/h1-9H,15H2,(H,17,18);;
- InChIKey=MAXHPWXOPQTMOT-UHFFFAOYSA-N
- Synonyms
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- 967-80-6
- Sulfaquinoxaline sodium salt
- Origin
- Chemically synthesized
- Biological activities
- Reversible inhibitor of the dithiothreitol-dependent reduction of both vitamin K epoxide and vitamin K quinone
- Therapeutic
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Anticoccidial
- Target
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Vitamin K epoxide
Quinone reductase
- Assay information
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Veterinary medicine to control cecal and intestinal coccidiosis (Eimeria tenella and Eimeria necatrix) infection in chickens (0.05% intermittently and 0.0125% continuously in the feed)
Reversible inhibition of the dithiothreitol-dependent reduction of both vitamin K epoxide and vitamin K quinone by rat liver microsomes in vitro (Ki = 1 μM)
- References
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Preusch PC, Hazelett SE, Lemasters KK
Sulfaquinoxaline inhibition of vitamin K epoxide and quinone reductase.
Arch Biochem Biophys, 269(1): 18-24 (1989) 
2916837
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Grumbles LC, Delaplane JP, Higgins TC
Sulfaquinoxaline in the Control of Eimeria tenella and Eimeria necatrix in Chickens on a Commercial Broiler Farm.
Science, 107(2773): 196 (1948) 17791764 doi: 10.1126/science.107.2773.196
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J. Am. Chem. Soc., 66: 1957-1959 (1944)