FSL0393
- Structure
- InChI=1S/C14H18N4O3/c1-3-4-9-15-13(19)18-11-8-6-5-7-10(11)16-12(18)17-14(20)21-2/h5-8H,3-4,9H2,1-2H3,(H,15,19)(H,16,17,20)
- InChIKey=RIOXQFHNBCKOKP-UHFFFAOYSA-N
- Synonyms
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- Origin
- Chemically synthesized
- Biological activities
- Inhibition of microtubule polymerization
- Therapeutic
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Antifungal
- Target
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β-Tubulin
- Assay information
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Fungi show large variations in sensitivity to benomyl. Based on sensitivity to benomyl, fungi can be classified into four categories, resistant (ED50 >gt;100 μg/ml), tolerant (ED50 = 10-100 μg/ml), sensitive (ED50 = 1-10 μg/ml), a
Inhibition of microtubule polymerization of bovine brain tubulin in vitro (IC50: 58.3 μM)
Inhibition of HeLa cell proliferetion (IC50: 5 μM) and the cell cycle progression during mitosis (IC50: ca 15 μM)
- References
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Gupta K, Bishop J, Peck A, Brown J, Wilson L, Panda D
Antimitotic antifungal compound benomyl inhibits brain microtubule polymerization and dynamics and cancer cell proliferation at mitosis, by binding to a novel site in tubulin.
Biochemistry, 43(21): 6645-6655 (2004) 15157098 doi: 10.1021/bi036112v
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Friedman PA, Platzer EG
Interaction of anthelmintic benzimidazoles and benzimidazole derivatives with bovine brain tubulin.
Biochim Biophys Acta, 544(3): 605-614 (1978) 728472
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Hein L Klopping
(1971). Carbamoyl substituted 2-aminobenzimidazoles. US3631176.
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G. J. Bollen, A. Fuchs
On the specificity of the in vitro and in vivo antifungal activity of benomyl
Netherlands Journal of Plant Pathology, 76(6): 299-312 (1970) doi: 10.1007/BF03041361