NPEdia

FSL0364

Structure
FSL0364
Synonyms
Origin
Chemically synthesized
Biological activities
Nonselective dopamne agonist
Therapeutic
Antiparkinsonian
Target
Dopamine receptor
Assay information
Non-ergoline dopamine agonist with high in vitro binding affinity for the dopamine D4 receptor (Ki = 4.4 nM), moderate affinity for the dopamine D2, D3, and D5 (Ki = 35-83, 26, and 15 nM, respectively), and adrenergic
Affinities (pKi values) for recombinant human dopamine receptors (hD1, hD2S, hD2L, hD3, hD4, hD5) are 6.43, 7.46, 7.08, 7.59, 8.36, 7.83, respectively
Affinities (pKi values) for recombinant human hα1-, hα2-, and hβ-adrenoceptors and native rat rα2D-ARs (hα1A, hα1B, hα1D, rα2D, hα2A, hα2B, hα2C, hβ1, hβ2
Affinities (pKi values) for serotonin h5-HT1 and h5-HT2 receptor subtypes and native histamine H1 receptors (h5-HT1A, h5-HT1B, h5-HT1D, h5-HT2A, h5-HT2B, h5-HT2C, H1) are 6.93, 5.53, 5.91, 6.92, 6.88, 6.99,
References