NPEdia

FSL0945

Structure
FSL0945
Synonyms
Origin
Chemically synthesized
Biological activities
Inhibition of acetylcholine transport
Therapeutic
Molecular beacon for a cholinergic marker
Target
Vesicular acetylcholine transporter (VAChT)
Assay information
Vesamicol binds tightly (Ki: 41 nM) to VAChT and inhibits transport of acetylcholine noncompetitively
(+/-)-Vesamicol inhibits in vitro acetylcholine storage (IC50: 40 nM), and shows acute toxicity in mice (LD50: 16 μmol/kg)
(-)-Vesamicol is more biologically active than (+)-vesamicol
References