NPEdia

FSL0350

Structure
FSL0350
Synonyms
Origin
Chemically synthesized
Biological activities
The class III antiarrhythmic action partly through blockade of multi channels
Therapeutic
Antiarrhythmic (class III)
Vasodilator
Target
Multi channels (K+, Na+, Ca2+)
PTX-sensitive G protein
Assay information
Blockage of multi channels (IC50 [μM]): ICaL (0.4-5.8), ICaT (2.4), INa (0.1-7.3), IK (6.3), IKNa (1.0), Ito (4.9), IKAch (2.0), IKATP (2.3), INa/Ca (3.3)
Activation of GTPase of reconstituted Gi/Go and Gi2 with EC50 values of 20 μM and 50 μM
Cytotoxicity against PANC1, H9C2, BRL-3A (GI50: 10-50 μM)
Antifungal activity against Heterobasidiomycetes, Ascomycetes, and Hyphomycetes (MIC50: 1-10 μM)
References