HTD1171
- Structure
- InChI=1S/C21H26ClN3OS/c22-17-6-7-21-19(16-17)25(18-4-1-2-5-20(18)27-21)9-3-8-23-10-12-24(13-11-23)14-15-26/h1-2,4-7,16,26H,3,8-15H2
- InChIKey=RGCVKNLCSQQDEP-UHFFFAOYSA-N
- Synonyms
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- 58-39-9
- Perphenazine
- PERPHENAZINE
- Origin
- Chemically synthesized
- Biological activities
- Dopamine antagonist
- Therapeutic
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Antipsycotic
- Target
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Dopamine D2 receptor
- Assay information
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Dopamine receptor Binding (Ki [nM]): D1 (4.5), D2 (0.27)
- References
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Seeman P
Targeting the dopamine D2 receptor in schizophrenia.
Expert Opin Ther Targets, 10(4): 515-531 (2006) 16848689 doi: 10.1517/14728222.10.4.515
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Seeman P
Atypical antipsychotics: mechanism of action.
Can J Psychiatry, 47(1): 27-38 (2002) 11873706
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Seeman P, Lee T, Chau-Wong M, Wong K
Antipsychotic drug doses and neuroleptic/dopamine receptors.
Nature, 261(5562): 717-719 (1976) 945467
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Creese I, Burt DR, Snyder SH
Dopamine receptor binding predicts clinical and pharmacological potencies of antischizophrenic drugs.
Science, 192(4238): 481-483 (1976) 3854
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Seeman P, Chau-Wong M, Tedesco J, Wong K
Brain receptors for antipsychotic drugs and dopamine: direct binding assays.
Proc Natl Acad Sci U S A, 72(11): 4376-4380 (1975) 1060115
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John W Cusic
(1956). N-(beta-acetoxyethyl)-n'-(chlorophenothiazinepropyl) piperazine. US2766235 A.