FSL0723
- Structure
- InChI=1S/C13H8Cl2N2O4/c14-7-1-4-12(18)9(5-7)13(19)16-11-3-2-8(17(20)21)6-10(11)15/h1-6,18H,(H,16,19)
- InChIKey=RJMUSRYZPJIFPJ-UHFFFAOYSA-N
- Synonyms
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- Origin
- Chemically synthesized
- Biological activities
- Inhibition of mitochondrial oxidative phosphorylation of parasitic helminths
Inhibition of Wnt/β-catenin signaling
- Therapeutic
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Anthelmintic
Antiparasitic
- Target
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Unknown
- Assay information
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Works by killing tapeworms on contact. Adult worms are rapidly killed, presumably due to uncoupling of oxidative phosphorylation
Anticancer activity (IC50 less than 1 μM for prostate PC-3 and DU145 and breast MDA-MB-231 and T-47D cells)
Antiviral activity (suppresses LRP6 expression and phosphorylation, blocks Wnt3A-induced β-catenin accumulation, inhibiting Wnt/β-catenin signaling
Inhibits gram-negative pathogen Pseudomonas aeruginosa quorum sensing
Targets acidic endosomes with broad antiviral effects
- References
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Mook RA Jr, Chen M, Lu J, Barak LS, Lyerly HK, Chen W
Small molecule modulators of Wnt/β-catenin signaling.
Bioorg Med Chem Lett, 23(7): 2187-2191 (2013) 23453073 doi: 10.1016/j.bmcl.2013.01.101
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Imperi F, Massai F, Ramachandran Pillai C, Longo F, Zennaro E, Rampioni G, Visca P, Leoni L
New life for an old drug: the anthelmintic drug niclosamide inhibits Pseudomonas aeruginosa quorum sensing.
Antimicrob Agents Chemother, 57(2): 996-1005 (2013) 23254430 doi: 10.1128/AAC.01952-12
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Jurgeit A, McDowell R, Moese S, Meldrum E, Schwendener R, Greber UF
Niclosamide is a proton carrier and targets acidic endosomes with broad antiviral effects.
PLoS Pathog, 8(10): e1002976 (2012) 23133371 doi: 10.1371/journal.ppat.1002976
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Lu W, Lin C, Roberts MJ, Waud WR, Piazza GA, Li Y
Niclosamide suppresses cancer cell growth by inducing Wnt co-receptor LRP6 degradation and inhibiting the Wnt/β-catenin pathway.
PLoS One, 6(12): e29290 (2011) 22195040 doi: 10.1371/journal.pone.0029290
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Andrews P, Thyssen J, Lorke D
The biology and toxicology of molluscicides, Bayluscide.
Pharmacol Ther, 19(2): 245-295 (1982) 6763710
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Wilkinson Samuel, Adamson Donald Wallace
(1954). Catalytic reduction of diphenyl alkanolamines and resulting products. US3079297.