FSL0372
- Structure
- InChI=1S/C14H22N2O3/c1-10(2)16-8-12(17)9-19-13-5-3-11(4-6-13)7-14(15)18/h3-6,10,12,16-17H,7-9H2,1-2H3,(H2,15,18)
- InChIKey=METKIMKYRPQLGS-UHFFFAOYSA-N
- Synonyms
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- Origin
- Chemically synthesized
- Biological activities
- Antihypertensive drug
- Therapeutic
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Arrhythmia
Hypertension
- Target
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β1 adrenoreceptor
- Assay information
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Selective β1 receptor antagonist (Ki = 170 nM)
- References
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Dolusić E, Larrieu P, Moineaux L, Stroobant V, Pilotte L, Colau D, Pochet L, Van den Eynde B, Masereel B, Wouters J, Frédérick R
Tryptophan 2,3-dioxygenase (TDO) inhibitors. 3-(2-(pyridyl)ethenyl)indoles as potential anticancer immunomodulators.
J Med Chem, 54(15): 5320-5334 (2011) 21726069 doi: 10.1021/jm2006782
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The Process of Drug Discovery and Development
Innovation in the Pharmaceutical Industry,: 46-51 (2003)