FSL0560
- Structure
- InChI=1S/C26H26F2N2.2ClH/c27-24-12-8-22(9-13-24)26(23-10-14-25(28)15-11-23)30-19-17-29(18-20-30)16-4-7-21-5-2-1-3-6-21;;/h1-15,26H,16-20H2;2*1H/b7-4+;;
- InChIKey=RXKMOPXNWTYEHI-RDRKJGRWSA-N
- Synonyms
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- 30484-77-6
- Flunarizine hydrochloride
- Origin
- Chemically synthesized
- Biological activities
- Blocking Ca2+ entry
Blocking histamine H1
- Therapeutic
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Anticonvulsant
- Target
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Voltage-dependent T-type calcium channel subunit α-1G,1H, 1I.
Histamine H1 receptor
Calmodulin
- Assay information
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Neuronal T-type Ca channel (Kd [nM]): α1G (530), α1H (3552), α1I (837)
Histamine H1 blocking activity
- References
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Overington JP, Al-Lazikani B, Hopkins AL
How many drug targets are there?
Nat Rev Drug Discov, 5(12): 993-996 (2006) 17139284 doi: 10.1038/nrd2199
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Santi CM, Cayabyab FS, Sutton KG, McRory JE, Mezeyova J, Hamming KS, Parker D, Stea A, Snutch TP
Differential inhibition of T-type calcium channels by neuroleptics.
J Neurosci, 22(2): 396-403 (2002) 11784784
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Van Nueten JM, Janssen PA
Comparative study of the effects of flunarizine and cinnarizine on smooth muscles and cardiac tissues.
Arch Int Pharmacodyn Ther, 204(1): 37-55 (1973) 4746630