FSL0422
- Structure
- InChI=1S/C23H26N2O4/c1-27-16-8-14-15(9-17(16)28-2)25-20(26)10-18-21-13-7-19-23(14,22(21)25)4-5-24(19)11-12(13)3-6-29-18/h3,8-9,13,18-19,21-22H,4-7,10-11H2,1-2H3/t13-,18?,19-,21-,22?,23+/m0/s1
- InChIKey=RRKTZKIUPZVBMF-PLNGPGDESA-N
- Synonyms
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- Origin
- Strychnos
Strychnos nux-vomica
- Biological activities
- Glycine receptors brocker
Inducion of apoptosis
Inhibition of COX-2 gene expression
Paralyzes inhibitory neurons
- Therapeutic
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Anticancer
- Target
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NF-κB
- Assay information
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Cytotoxic effect (IC50 [mM]): HepG2 (0.32), Vero (0.622), MCF-7 (0.48), HL-60 (0.107)
DNA re-replication in SW480 colon adenocarcinoma cells (IC50 = 0.41 μM)
- References
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J. Leuk. Lymphoma., 22: 593-596 (2013)
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Zhongguo Zhong Yao Za Zhi, 37: 1269-1273 (2012)
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Agrawal SS, Saraswati S, Mathur R, Pandey M
Cytotoxic and antitumor effects of brucine on Ehrlich ascites tumor and human cancer cell line.
Life Sci, 89(5-6): 147-158 (2011) 21684292 doi: 10.1016/j.lfs.2011.05.020
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Deng XK, Yin W, Li WD, Yin FZ, Lu XY, Zhang XC, Hua ZC, Cai BC
The anti-tumor effects of alkaloids from the seeds of Strychnos nux-vomica on HepG2 cells and its possible mechanism.
J Ethnopharmacol, 106(2): 179-186 (2006) 16442763 doi: 10.1016/j.jep.2005.12.021
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Acta. Pharmacol. Sin., 19: 425-428 (1998)
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Ann. Chim. Phys. Ser., 10: 142-177 (1819)
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Ann. Chim. Phys. Ser., 8: 323-324 (1818)