FSL0954
- Structure
- InChI=1S/C16H24N2.ClH/c1-11-8-13(16(3,4)5)9-12(2)14(11)10-15-17-6-7-18-15;/h8-9H,6-7,10H2,1-5H3,(H,17,18);1H
- InChIKey=YGWFCQYETHJKNX-UHFFFAOYSA-N
- Synonyms
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- 1218-35-5
- Xylometazoline hydrochloride
- Origin
- Chemically synthesized
- Biological activities
- α-adrenoceptor agonist
Vasoconstriction
- Therapeutic
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Nasal catarrh
- Target
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α-adrenergic receptor
- Assay information
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Binding affinity for α1-adrenergic receptor (Ki = 91 nM)
- References
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Haenisch B, Walstab J, Herberhold S, Bootz F, Tschaikin M, Ramseger R, Bönisch H
Alpha-adrenoceptor agonistic activity of oxymetazoline and xylometazoline.
Fundam Clin Pharmacol, 24(6): 729-739 (2010) 20030735 doi: 10.1111/j.1472-8206.2009.00805.x
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Law H, Dukat M, Teitler M, Lee DK, Mazzocco L, Kamboj R, Rampersad V, Prisinzano T, Glennon RA
Benzylimidazolines as h5-HT1B/1D serotonin receptor ligands: a structure-affinity investigation.
J Med Chem, 41(13): 2243-2251 (1998) 9632357 doi: 10.1021/jm970513p