FSL0888
- Structure
- InChI=1S/C11H12N4O2S/c1-8-6-7-13-11(14-8)15-18(16,17)10-4-2-9(12)3-5-10/h2-7H,12H2,1H3,(H,13,14,15)
- InChIKey=QPPBRPIAZZHUNT-UHFFFAOYSA-N
- Synonyms
-
- Origin
- Chemically synthesized
- Biological activities
- Inhibition of folic acid synthesis in bacteria
- Therapeutic
-
Antibacterial
- Target
-
Dihydropteroate synthase (DHPS)
- Assay information
-
Competitive inhibition of DHPS from P. carinii (IC50 = 0.078 mM)
- References
-
-
Hong YL, Hossler PA, Calhoun DH, Meshnick SR
Inhibition of recombinant Pneumocystis carinii dihydropteroate synthetase by sulfa drugs.
Antimicrob Agents Chemother, 39(8): 1756-1763 (1995) 7486915
-
James M Sprague
(1946). Diazine compounds. US2407966.