FSL0817
- Structure
- InChI=1S/C19H29NO.ClH/c21-19(17-9-3-1-4-10-17,18-11-5-2-6-12-18)13-16-20-14-7-8-15-20;/h1,3-4,9-10,18,21H,2,5-8,11-16H2;1H
- InChIKey=ZFSPFXJSEHCTTR-UHFFFAOYSA-N
- Synonyms
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- 1508-76-5
- Procyclidine hydrochloride
- Origin
- Chemically synthesized
- Biological activities
- An anticholinergic effect (muscarinic antagonist)
- Therapeutic
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Anticholinergic
Antiparkinsonian
- Target
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Muscarinic acetylcholine receptor M1, M2, and M4
- Assay information
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(R)-Procyclidine showed a higher affinity for human neuroblastoma NB-OK 1 muscarinic M1 (pKi 8.4) and rat striatum muscarinic M4 (pKi 8.1) receptors, as compared to rat cardiac M2 recep
(S)-Procyclidine had a lower affinity than (R)-procyclidine
- References
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Waelbroeck M, Camus J, Tastenoy M, Lambrecht G, Mutschler E, Tacke R, Christophe J
Stereoselectivity of procyclidine binding to muscarinic receptor subtypes M1, M2 and M4.
Eur J Pharmacol, 189(2-3): 135-142 (1990) 2253700
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DUFFIN WM, GREEN AF
The pharmacological properties of the optical isomers of benzhexol, procyclidine, tricyclamol and related compounds.
Br J Pharmacol Chemother, 10(3): 383-386 (1955) 13269719
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Wilkinson Samuel, Adamson Donald Wallace
(1954). Catalytic reduction of diphenyl alkanolamines and resulting products. US2682543.