FSL0809
- Structure
- InChI=1S/C19H24N2O2/c22-18-13-20(19(23)15-7-2-1-3-8-15)12-17-16-9-5-4-6-14(16)10-11-21(17)18/h4-6,9,15,17H,1-3,7-8,10-13H2
- InChIKey=FSVJFNAIGNNGKK-UHFFFAOYSA-N
- Synonyms
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- Origin
- Chemically synthesized
- Biological activities
- Increases the permeability of the membranes towards calcium ions
- Therapeutic
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Anthelmintic
Antihydatidosis
Broad spectrum
- Target
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Schistosome Calcium (Ca2+) Channel
- Assay information
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Inhibition of nucleoside uptake in living worms and may be specifically related to adenosine uptake or signaling (mouse LD50 = 376mg/kg)
Treatment of children (n = 592) infected with Schistosoma haematobium in a single dose of praziquantel (40 mg/kg), showing high activity (cure rate >gt; 83% and egg reduction rate >gt; 98%)
- References
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Tchuenté LA, Shaw DJ, Polla L, Cioli D, Vercruysse J
Efficacy of praziquantel against Schistosoma haematobium infection in children.
Am J Trop Med Hyg, 71(6): 778-782 (2004) 15642971
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Seubert J, Pohlke R, Loebich F
Synthesis and properties of Praziquantel, a novel broad spectrum anthelmintic with excellent activity against Schistosomes and Cestodes.
Experientia, 33(8): 1036-1037 (1977) 891804