FSL0316
- Structure
- InChI=1S/C4H6N4O3S2/c1-2(9)6-3-7-8-4(12-3)13(5,10)11/h1H3,(H2,5,10,11)(H,6,7,9)
- InChIKey=BZKPWHYZMXOIDC-UHFFFAOYSA-N
- Synonyms
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- Origin
- Chemically synthesized
- Biological activities
- Inhibition of carbonic anhydrase
- Therapeutic
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Antiglaucoma
Diuretics
- Target
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Carbonic anhydrase
- Assay information
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human carbonic anhydrases (CAII, IV, IX etc.): Ki =2.5-250 nM
Invasion of renal cancer cells (Caki-1, Caki-2, ACHN, and A-498, invasion rate 18-74% at 10 μM)
Cell proliferation in pancreatic cancer cells (AsPC-1 and PANC-1) at 100 μM
- References
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Supuran CT
Carbonic anhydrases: novel therapeutic applications for inhibitors and activators.
Nat Rev Drug Discov, 7(2): 168-181 (2008) 18167490 doi: 10.1038/nrd2467
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Juhász M, Chen J, Lendeckel U, Kellner U, Kasper HU, Tulassay Z, Pastorekova S, Malfertheiner P, Ebert MP
Expression of carbonic anhydrase IX in human pancreatic cancer.
Aliment Pharmacol Ther, 18(8): 837-846 (2003) 14535878
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Parkkila S, Rajaniemi H, Parkkila AK, Kivela J, Waheed A, Pastorekova S, Pastorek J, Sly WS
Carbonic anhydrase inhibitor suppresses invasion of renal cancer cells in vitro.
Proc Natl Acad Sci U S A, 97(5): 2220-2224 (2000) 10688890 doi: 10.1073/pnas.040554897
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J. Am. Chem. Soc., 72: 4890-4892 (1950)
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J. Am. Chem. Soc., 72: 4893-4896 (1950)