NPEdia

FSL0732

Structure
FSL0732
Synonyms
Origin
Chemically synthesized
Biological activities
antineoplastic
Inhibition of microtubule polymerization
Therapeutic
Anticancer
Target
Tubulin
Assay information
Nocodazole exhibits anticancer activity and is also widely used in cell biology research as a tool for synchronization of the cell division cycle. Mechanistically, nocodazole binds to tubulin with apparent Ka of (4±1) x105
It caused the Golgi apparatus dispersion in mammalian fibroblast cells
It exhibits inhibitory activity of cell division in HeLa cells (IC50: 22 nM)
It induces apoptosis in HCT116 cells (fully effective concentration: 200 ng/ml)
References