NPEdia

FSL0431

Structure
FSL0431
Synonyms
Origin
Epicauta
Lytta vesicatoria
Biological activities
Inhibition of protein phosphatase 2A
Therapeutic
Anticancer
Target
Protein phosphatase 2A (PP2A)
Assay information
IC50 of phosphorylase a phosphatase activity of PP2A AC form (EC 3.1.3.16) by cantharidin and okadaic acid treatment are 50 nM and 12 nM, respectively
Inhibition of purified catalitic subunits of PP2A (IC50=0.16 μM by cantharidin and 0.04 nM by okadaic acid) and PP1 (IC50=1.7 μM by cantharidin)
Growth inhibition (IC50) of human pancreatic cancer cells (PANC-1 and CFPAC-1) at 72 h after cantharidin treatment are 9.42 and 7.25 μM, respectively. In comparison, the IC50 of normal human pancreatic dust cells is
References