NPEdia

FSL0429

Structure
FSL0429
Synonyms
Origin
Camptotheca acuminata
Biological activities
antineoplastic
Inhibition of DNA synthesis
Therapeutic
Anticancer
Target
Topoisomerase I
Assay information
Stabilization of the cleavable complex formed between DNA and topoisomerase I, preventing DNA re-ligation and causing DNA synthesis inhibition
Growth inhibition against various cancer cell lines (9KB, HL-60, L1210, MOLT4, KG1 at 0.01-0.1 μg/ml)
References