FSL0370

Structure

• InChI=1S/C9H8O4/c1-6(10)13-8-5-3-2-4-7(8)9(11)12/h2-5H,1H3,(H,11,12)
• InChIKey=BSYNRYMUTXBXSQ-UHFFFAOYSA-N

Synonyms

• 50-78-2
• Aspirin

Origin

Chemically synthesized

Biological activities

Inhibition of the production of prostaglandins and thromboxanes

Therapeutic

Analgesic and antipyretic
Antiinflammatory
Antiplatelet

Target

Cyclooxygenase

Assay information

Inhibition of the production of prostagrandins and thromboxanes (1, 2) by irreversible inhibition of COX (IC₅₀: 5 μg/ml for COX-1, 210 μg/ml for COX-2)
Growth inhibition against various cancer cell linces at sub-mM range

References

• Mahdi JG, Mahdi AJ, Mahdi AJ, Bowen ID
  The historical analysis of aspirin discovery, its relation to the willow tree and antiproliferative and anticancer potential.
  Cell Prolif, 39(2): 147-155 (2006)  16542349  doi: 10.1111/j.1365-2184.2006.00377.x
• Mitchell JA, Akarasereenont P, Thiemermann C, Flower RJ, Vane JR
  Selectivity of nonsteroidal antiinflammatory drugs as inhibitors of constitutive and inducible cyclooxygenase.
  Proc Natl Acad Sci U S A, 90(24): 11693-11697 (1993)  8265610
• H. Dreser
  Pharmakologisches über Aspirin (Acetylsalicylsäure)
  Pflugers Arch, 76(5-6): 306-318 (1899)  doi: 10.1007/BF01662127
• T.J. Maclagan
  THE TREATMENT OF ACUTE RHEUMATISM BY SALICIN AND SALICYLIC ACID
  Lancet, 4: 342-383 (1876)  doi: 10.1016/S0140-6736(02)46061-8