FSL0647
- Structure
- InChI=1S/C26H30O8/c1-22(2)15-9-16(27)24(4)14(25(15)12-31-18(28)10-17(25)33-22)5-7-23(3)19(13-6-8-30-11-13)32-21(29)20-26(23,24)34-20/h6,8,11,14-15,17,19-20H,5,7,9-10,12H2,1-4H3/t14-,15-,17-,19-,20?,23-,24-,25+,26+/m0/s1
- InChIKey=KBDSLGBFQAGHBE-QDTQPDKMSA-N
- Synonyms
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- 1180-71-8
- Limonin, from Grapefruit
- Origin
- Citrus
- Biological activities
- Inhibition of HIV-1replication
- Therapeutic
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Anticancer
Antiviral
- Target
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Unknown
- Assay information
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Inhibition of HIV-1 replication (human peripheral blood mononuclear cells and on monocytes/macrophages, EC50: ca. 60 μM)
Growth inhibition against some cancer cells ( IC50: MCF7, 13.48 μg/ml; SW480, 54.74 μM)
- References
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Chidambara Murthy KN, Jayaprakasha GK, Kumar V, Rathore KS, Patil BS
Citrus limonin and its glucoside inhibit colon adenocarcinoma cell proliferation through apoptosis.
J Agric Food Chem, 59(6): 2314-2323 (2011) 21338095 doi: 10.1021/jf104498p
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Battinelli L, Mengoni F, Lichtner M, Mazzanti G, Saija A, Mastroianni CM, Vullo V
Effect of limonin and nomilin on HIV-1 replication on infected human mononuclear cells.
Planta Med, 69(10): 910-913 (2003) 14648393 doi: 10.1055/s-2003-45099
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Tian Q, Miller EG, Ahmad H, Tang L, Patil BS
Differential inhibition of human cancer cell proliferation by citrus limonoids.
Nutr Cancer, 40(2): 180-184 (2001) 11962254 doi: 10.1207/S15327914NC402_15
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J. Am. Chem. Soc., 62: 1307-1309 (1940)
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Liebigs Ann., 40: 317-318 (1841)