NPEdia

FSL0680

Structure
FSL0680
Synonyms
Origin
Leucaena leucocephala
Mimosa pudica
Biological activities
Inhibition of DNA replication and cell cycle arrest at G1
Therapeutic
DNA synthesis inhibitor
Target
Iron/zinc chelation
Serine methyltransferase
Deoxyhypusyl hydroxylase
Assay information
Cell growth inhibition of lung cancer cells by 40-60% at 400 μM
Cell growth inhibition of brest cancer cells by more than 90% at 400 μM
Inhibition of the transcription of the cytoplasmic serine hydroxymethyltransferase gene (SHMT1)
Inhibition of deoxyhypusyl hydroxylase (50 μM)
Inhibition of tyrosinase (IC50=3.68 μM)
Inhibition of the binding of Ctf4 to chromatin
References