NPEdia

FSL0754

Structure
FSL0754
Synonyms
Origin
Acokanthera oubaio
Strophanthus gratus
Biological activities
An increase in intracellular sodium and calcium concentrations
Therapeutic
Cardiotonic
Target
Sodium/potassium-transporting ATPase
Assay information
Inhibition of human Na+/K+-ATPase α1β1 (Kd = 13.3 ± 5.2 nM), α2β1 (Kd = 32.8 ± 15.7 nM), α3β1 (Kd = 16.7 ± 1.8 nM)
Induction for the apoptosis in MDA-MB-231 breast cancer cells by increasing free calcium concentration and by activating caspase-3 (IC50 = 150 nM (24h), 90 nM (48 h))
Antiproliferative and apoptotic effects in several cancer cell lines, including 1. Small cell lung cancer cell: H69 AR (IC50 = 45 nM, MRP-associated resistance), NCl-H69 (IC50 = 70 nM, parental resistance); 2. Histiocy
Cytoprotective effects of cardiac glycosides in human tumor cell at the low concentrations (0.1-10 nM)
References