FSL0760
- Structure
- InChI=1S/C23H28O11/c1-20-9-22(29)13-7-23(20,32-18-16(27)15(26)14(25)12(8-24)31-18)21(13,19(33-20)34-22)10-30-17(28)11-5-3-2-4-6-11/h2-6,12-16,18-19,24-27,29H,7-10H2,1H3/t12-,13-,14-,15+,16-,18+,19-,20-,21+,22+,23+/m1/s1
- InChIKey=YKRGDOXKVOZESV-MRPXEQBUSA-N
- Synonyms
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- 23180-57-6
- FSL0760
- Paeoniflorin
- Origin
- Paeonia lactiflora
- Biological activities
- Inhibition of inflammatory responses
inhibition of oxidative stress and Ca2+ overload
- Therapeutic
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Analgesic
Antiallergic
Antidepressant
Antihyperglycemia
Antiinflammatory
- Target
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Intercellular adhesion molecule-1 (ICAM-1)
- Assay information
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Delayed protection in mice (50, 100 mg/kg) from lipopolysaccharide (LPS)-induced acute lung injury (ALI) by alleviating inflammatory cell infiltration and microvascular permeability
Inhibition of proinflammatory cytokine expression through down-regulating the activation of p38 MAPK, JNK, and NF-kB playing an important role in the action of paeoniflorin
Delayed protection in the ischemia-injured rats (5 mg/kg) decreasing infarct volume (250.1 ± 17.2% mm3 - 106.0 ± 11.7% mm3) via inhibiting MAPKs/NF-kB-mediated inflammatory responses
Protection against glutamate-induced apoptotic cell death in PC12 cells (1, 10, 50 μM, viability increasing from 80, 88 and 92% of the control value). The protective effect is mediated by antioxidant mechanisms and Ca2+ antago
Inhibition of the ICAM-1 expression level elevated in LPS-induced U937 cells and TNF-α-stimulated human umbilical vein endothelial cells by utilizing RT-PCR
Inhibition of dextran sulface sodium (DSS)-induced activation for ERK1/2, JNK and p38 MAPKs
Inhibition of 2,2'-azinobis-(3-thylbenzothiazoline-6-sulfonic acid) formation, which is a substrate of peroxidase (IC50 = 419.7 μM)
Increase of advanced glycation end product-induced glutathione peroxidase and catalase activities (10-8-10-4 M, pretreatment)
- References
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Zhang J, Dou W, Zhang E, Sun A, Ding L, Wei X, Chou G, Mani S, Wang Z
Paeoniflorin abrogates DSS-induced colitis via a TLR4-dependent pathway.
Am J Physiol Gastrointest Liver Physiol, 306(1): G27-G36 (2014) 24232001 doi: 10.1152/ajpgi.00465.2012
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Zhang MH, Feng L, Zhu MM, Gu JF, Wu C, Jia XB
Antioxidative and anti-inflammatory activities of paeoniflorin and oxypaeoniflora on AGEs-induced mesangial cell damage.
Planta Med, 79(14): 1319-1323 (2013) 23881455 doi: 10.1055/s-0033-1350649
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Guo RB, Wang GF, Zhao AP, Gu J, Sun XL, Hu G
Paeoniflorin protects against ischemia-induced brain damages in rats via inhibiting MAPKs/NF-κB-mediated inflammatory responses.
PLoS One, 7(11): e49701 (2012) 23166749 doi: 10.1371/journal.pone.0049701
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Zhou H, Bian D, Jiao X, Wei Z, Zhang H, Xia Y, He Y, Dai Y
Paeoniflorin protects against lipopolysaccharide-induced acute lung injury in mice by alleviating inflammatory cell infiltration and microvascular permeability.
Inflamm Res, 60(10): 981-990 (2011) 21744312 doi: 10.1007/s00011-011-0359-9
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Jin L, Zhang LM, Xie KQ, Ye Y, Feng L
Paeoniflorin suppresses the expression of intercellular adhesion molecule-1 (ICAM-1) in endotoxin-treated human monocytic cells.
Br J Pharmacol, 164(2b): 694-703 (2011) 21542832 doi: 10.1111/j.1476-5381.2011.01464.x
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Mao QQ, Zhong XM, Feng CR, Pan AJ, Li ZY, Huang Z
Protective effects of paeoniflorin against glutamate-induced neurotoxicity in PC12 cells via antioxidant mechanisms and Ca(2+) antagonism.
Cell Mol Neurobiol, 30(7): 1059-1066 (2010) 20577899 doi: 10.1007/s10571-010-9537-5
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Chem. Pharm. Bull., 11: 372-378 (1963)