NPEdia

FSL0588

Structure
FSL0588
Synonyms
Origin
Chemically synthesized
Biological activities
Insulin secretion
Therapeutic
Antidiabetic
Target
Sulfonylurea receptors (SUR-1)
Assay information
Block of KATP channels in pancreatic beta-cells (IC50 = 184 ± 30 nM), cardiac myocytes (IC50 = 19.5 ± 5.4 μM) and arterial smooth muscle (IC50 = 37.9 ± 1.0 μM) isolated from Mouse
Reduction in the blood glucose level on alloxan induced diabetic Albino Wistar rats fed with pellet contaied 2% gliclazide
Biphasic reduction of blood glucose levels in normal and diabetic rats with maximum activity attained at 2h and 8h, and hypoglycemic activity for rabbits (Max: 4h post dose)
Marked reduction of blood glucose levels in rats/rabbits in combination with aminodarone
References