FSL0620
- Structure
- InChI=1S/C19H24N2/c1-20(2)14-7-15-21-18-10-5-3-8-16(18)12-13-17-9-4-6-11-19(17)21/h3-6,8-11H,7,12-15H2,1-2H3
- InChIKey=BCGWQEUPMDMJNV-UHFFFAOYSA-N
- Synonyms
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- Origin
- Chemically synthesized
- Biological activities
- Inhibition of the neuronal reuptake of neurotransmitters, noradrenaline and serotonin
- Therapeutic
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Antidepressant
- Target
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Sodium-dependent noradrenaline transporter (NET)
Sodium-dependent serotonin transporter (5HTT)
- Assay information
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Inhibitor of serotonin transporter (Kd = 1.4 nM) and noradrenaline transporter (Kd = 37 nM)
Inhibitor of dopamine transporter (Kd = 8.5 μM)
Reduce human HT29 colon carcinoma cell viability (IC50 = 53 μM)
- References
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Arimochi H, Morita K
Characterization of cytotoxic actions of tricyclic antidepressants on human HT29 colon carcinoma cells.
Eur J Pharmacol, 541(1-2): 17-23 (2006) 16753142 doi: 10.1016/j.ejphar.2006.04.053
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Iversen L
Neurotransmitter transporters and their impact on the development of psychopharmacology.
Br J Pharmacol, 147 Suppl 1: S82-S88 (2006) 16402124 doi: 10.1038/sj.bjp.0706428
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Tatsumi M, Groshan K, Blakely RD, Richelson E
Pharmacological profile of antidepressants and related compounds at human monoamine transporters.
Eur J Pharmacol, 340(2-3): 249-258 (1997) 9537821
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AZIMA H, VISPO RH
Imipramine; a potent new anti-depressant compound.
Am J Psychiatry, 115(3): 245-246 (1958) 13571443
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KUHN R
[Treatment of depressive states with an iminodibenzyl derivative (G 22355)].
Schweiz Med Wochenschr, 87(35-36): 1135-1140 (1957) 13467194