FSL0407
- Structure
- InChI=1S/C22H29FO5/c1-12-8-16-15-5-4-13-9-14(25)6-7-19(13,2)21(15,23)17(26)10-20(16,3)22(12,28)18(27)11-24/h6-7,9,12,15-17,24,26,28H,4-5,8,10-11H2,1-3H3/t12-,15?,16?,17-,19-,20-,21-,22-/m0/s1
- InChIKey=UREBDLICKHMUKA-REKGUKDCSA-N
- Synonyms
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- 378-44-9
- Betamethasone
- Celestone
- Origin
- Chemically synthesized
- Biological activities
- Function as a potent glucocorticoid steroid
- Therapeutic
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Antiinflammatory
Immunosuppressive
- Target
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Glucocorticoid receptor
- Assay information
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Glucocorticoid receptor agonist (Kd = 8.31 nM)
Antiinflammatory activity (IC50 = 1.4 μg/ml)
Inhibition of basal phospholipase A2 activity (IC50 = 1.4 μg/ml)
Synegistic effect of caffeine and betametasone on expression of surfactant protein B (SP-B) mRNA
- References
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Fehrholz M, Bersani I, Kramer BW, Speer CP, Kunzmann S
Synergistic effect of caffeine and glucocorticoids on expression of surfactant protein B (SP-B) mRNA.
PLoS One, 7(12): e51575 (2012) 23272120 doi: 10.1371/journal.pone.0051575
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Buchwald P
Glucocorticoid receptor binding: a biphasic dependence on molecular size as revealed by the bilinear LinBiExp model.
Steroids, 73(2): 193-208 (2008) 18022656 doi: 10.1016/j.steroids.2007.10.001
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Wolff ME, Baxter JD, Kollman PA, Lee DL, Kuntz ID, Bloom E, Matulich DT, Morris J
Nature of steroid-glucocorticoid receptor interactions: thermodynamic analysis of the binding reaction.
Biochemistry, 17(16): 3201-3208 (1978) 567487
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Blackwell GJ, Flower RJ, Nijkamp FP, Vane JR
Phospholipase A2 activity of guinea-pig isolated perfused lungs: stimulation, and inhibition by anti-inflammatory steroids.
Br J Pharmacol, 62(1): 79-89 (1978) 620100
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Taub David, Norman L Wendler, Harry L Slates
(1962). US3053865.
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GLYN JH
Speculations on allergic and infective arthritis.
Proc R Soc Med, 54: 684-686 (1961) 13706121