NPEdia

FSL0622

Structure
FSL0622
Synonyms
Origin
Chemically synthesized
Biological activities
Inhibition of the COX-dependent formation of prostaglandin precursors
Therapeutic
Antiinflammatory
Antipyretic
Target
COX-1
COX-2
Phospholipase A2 (PLA2)
Assay information
Inhibitor of phospholipase A2 (IC50 = 145 mM)
Inhibitor of the enzymatic activities of COX-1 (IC50 = 0.01 μg/ml) and COX-2 (IC50 = 0.6 μg/ml)
Inhibitor of the enzymatic activities of hCOX-1 (IC50 = 0.08 mM) and hCOX-2 (IC50 = 0.96 mM)
Inhibitor of the production of prostaglandins
Inducer of differentiation of C3H10T1/2 cells to adipocytes through binding to PPARγ (EC50 = approximately 80 μM)
References