FSL0739
- Structure
- InChI=1S/C31H36N2O11/c1-14(2)7-8-16-13-17(9-11-19(16)34)27(37)33-21-22(35)18-10-12-20(15(3)24(18)42-28(21)38)41-29-23(36)25(43-30(32)39)26(40-6)31(4,5)44-29/h7,9-13,23,25-26,29,34-36H,8H2,1-6H3,(H2,32,39)(H,33,37)/t23-,25+,26-,29-/m1/s1
- InChIKey=YJQPYGGHQPGBLI-KGSXXDOSSA-N
- Synonyms
-
- 303-81-1
- Albamix
- Albamycin
- Antibiotic PA-93
- Cardelmycin
- Cathocin
- Cathomycin
- Crystallinic acid
- Inamycin
- MS0A0293
- Novo-R
- Novobiocin
- Novobiocin
- PA 93
- Robiocina
- Sirbiocina
- Spheromycin
- Stilbiocina
- Streptonivicin
- U 6391
- Origin
- Streptomyces niveus
- Biological activities
- Inhibition of DNA replication in bacteria
- Therapeutic
-
Antibacterial
- Target
-
GyrB
ParE
- Assay information
-
Inhibitor of DNA gyrase in E. coli (IC50 = 0.5 μM)
Inhibitor of GryB (IC50 = 0.03 μM) and ParE (IC50 = 1.32 μM)
MIC [μg/ml]: S. aureus (0.125), E. faecalis (8), E. coli (8)
- References
-
-
East SP, White CB, Barker O, Barker S, Bennett J, Brown D, Boyd EA, Brennan C, Chowdhury C, Collins I, Convers-Reignier E, Dymock BW, Fletcher R, Haydon DJ, Gardiner M, Hatcher S, Ingram P, Lancett P, Mortenson P, Papadopoulos K, Smee C, Thomaides-Brears HB, Tye H, Workman J, Czaplewski LG
DNA gyrase (GyrB)/topoisomerase IV (ParE) inhibitors: synthesis and antibacterial activity.
Bioorg Med Chem Lett, 19(3): 894-899 (2009) 19095445 doi: 10.1016/j.bmcl.2008.11.102
-
Galm U, Heller S, Shapiro S, Page M, Li SM, Heide L
Antimicrobial and DNA gyrase-inhibitory activities of novel clorobiocin derivatives produced by mutasynthesis.
Antimicrob Agents Chemother, 48(4): 1307-1312 (2004) 15047534
-
Lanoot B, Vancanneyt M, Cleenwerck I, Wang L, Li W, Liu Z, Swings J
The search for synonyms among streptomycetes by using SDS-PAGE of whole-cell proteins. Emendation of the species Streptomyces aurantiacus, Streptomyces cacaoi subsp. cacaoi, Streptomyces caeruleus and Streptomyces violaceus.
Int J Syst Evol Microbiol, 52(Pt 3): 823-829 (2002) 12054245
-
Gellert M, O'Dea MH, Itoh T, Tomizawa J
Novobiocin and coumermycin inhibit DNA supercoiling catalyzed by DNA gyrase.
Proc Natl Acad Sci U S A, 73(12): 4474-4478 (1976) 794878
-
SMITH CG, DIETZ A, SOKOLSKI WT, SAVAGE GM
Streptonivicin, a new antibiotic. I. Discovery and biologic studies.
Antibiot Chemother (Northfield), 6(2): 135-142 (1956) 24543916
-
J. Am. Chem. Soc., 77: 6710-6711 (1955)