NPEdia

FSL0875

Structure
FSL0875
Synonyms
Origin
Streptomyces ambofaciens
Biological activities
Inhibition of bacterial protein synthesis
Therapeutic
Antibacterial
Target
bacterial 50S ribosomal subunits
Assay information
LD50 for the sulfate salt in mice is 1.5-2.0 Gm/Kg (subcutaneous route) and 0.15-0.25 Gm/Kg (intravenous route)
Antibiotic activity against S. pneumoniae (0.2 μg/ml) and S. pyogenes (0.8 μg/ml)
Low antiviotic activity against Gram-negative bacteria excluding Haemophilus pertussis
Antibiotic activity against erythromycin-registant S. pyogenes (MIC50 = 0.06 μg/ml) and erythromycin-registant S. pneumoniae (MIC50 = 4 μg/ml)
References