NPEdia

FSL0482

Structure
FSL0482
Synonyms
Origin
Paenibacillus polymyxa var. colistinus
Biological activities
Disruption of the outer cell membrane of Gram-negative bacilli
Therapeutic
Antibacterial
Target
Bacterial outer cell membrane
Assay information
Binding and neutralizing lipopolysaccharide (LPS) and preventing the pathophysiologic effects of endotoxin in the circulation
Binding to phospholipids in the outer cell membrane of Gram-negative bacteria. Competitively displaces divalent cations from the phosphate groups of membrane lipids, which leads to disruption of the outer cell membrane, leakage of intracell
MICs for susceptible strains, 1 to 4 μg/ml MICs for resisrant strains were >gt;128 μg/ml
Effective antimicrobial effect in vivo using E. coli infected mice at 1 mg/Kg
References